P3-394: TIME BETWEEN MILESTONE EVENTS IN THE ALZHEIMER'S DISEASE AMYLOID CASCADE

Alzheimers Disease: A Novel Hypothesis for the Development and the Subsequent Role of Beta Amyloid

Spirochetes, biofilms, and innate immune system activity have all been recently found in the brains of Alzheimer’s disease patients. The mechanism and actions of those factors in producing the disease were discussed in those studies. However, neither the production nor the role of beta amyloid was included in the discussion of those studies. In this commentary, we hypothesize how the developmen...

The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind

Since its discovery in 1984, the beta amyloid peptide has treaded the boards of neurosciences as the star molecule in Alzheimer's disease pathogenesis. In the last decade, however, this vision has been challenged by evidence-based medicine showing the almost complete failure of clinical trials that experimented anti-amyloid therapies with great hopes. Moreover, data have accumulated which clear...

Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.

Here I recap the scientific and personal background of the delineation of the amyloid cascade hypothesis for Alzheimer's disease that I wrote with Gerry Higgins and the events leading to the writing of that influential review.

Alzheimer disease therapy: can the amyloid cascade be halted?

Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review

Since 1992, the amyloid cascade hypothesis has played the prominent role in explaining the etiology and pathogenesis of Alzheimer's disease (AD). It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques (SPs) and then to neurofibrillary tangles (NFTs), neuronal cell death, and ultimately dementia. While there is substan...